Serum Cholinesterases in Undernutrition

The temperature activity relationships of serum cholinesterases.

A study has been made of the temperature activity relationships of the serum cholinesterase variants differentiated by means of dibucaine and fluoride inhibition. Using benzoylcholine as substrate, there is a characteristic temperature activity curve for each phenotype, and, for those most sensitive to succinyldicholine, this differs radically from that of the normal enzyme.A true index of seru...

Effects of metoclopramide on serum and erythrocyte cholinesterases.

Cholinesterases in human skin.

This study concerns the distribution of cholinesterases in human skin. Previous work on this subject was published last year by Hurley, Shelley and Koelle (1) These authors used a method originated by Koelle (2, 3). In Koelle's method, acetyithiocholine and butyryithiocholine are used as substrates. It is assumed that acetyithiocholine is split by specific acetyicholinesterase as well as by non...

The cholinesterases.

In 1914 Sir Henry Dale (1) suggested that an enzyme which degrades the esters of choline played a role in neurotransmission within the autonomic and somatic motor nervous systems and that this enzyme, acetylcholinesterase, was the target of action of the drug, physostigmine (eserine). In the intervening 75 years, inhibition of the enzyme has been used to augment both the nicotinic and muscarini...

Next Effort in Cholinesterases Biosensors

Acetyl cholinesterase (AChE) and butyryl cholinesterase (BChE) are two known enzymes in the body with ability to hydrolyze acetylcholine. While AChE plays crucial role in acetylcholine mediated neurotransmission, BChE is secreted from livers to plasma and biological role of the enzyme is not fully understood [1]. The both cholinesterases are very sensitive to inhibition by nerve agents such as ...